9/14/2023 0 Comments M6a dot blot protocolEven in the clinic, oral administration of a low dose (50 or 100 mg/day) for systemic sclerosis or lupus erythematosus for 1 week has caused cardiac electrical alteration (prolonged QT interval) in some patients. Further, CYP is widely used in the treatment of other diseases, such as refractory neuromyelitis optica spectrum disorder (200 mg/kg) ( 6) and rapidly progressive systemic sclerosis (300 mg/kg) ( 7), all of reportedly cause severe cardiotoxicity. Up to 28% of patients who received a high dose of CYP suffered from cardiac arrhythmias ( 3) and even heart failure ( 5). One traditional antineoplastic agent, cyclophosphamide (CYP), is employed in the treatment of various cancers, including breast, lymphoid, and hematologic malignancies ( 4). Both conventional chemotherapies and targeted drug therapies reportedly induce cardiovascular toxicity events. Many countries and regions have issued relevant practice guidelines for cardiovascular toxicity induced by cancer treatments ( 3). Tumor therapy-induced cardiotoxicity as a common side effect has received increasing attention. Our results revealed a novel mechanism for m6A methylation-dependent regulation of JPH2, which provides new strategies for the treatment and prevention of CYP-induced cardiotoxicity.Īlthough improved treatments have been effective in increasing the survival of patients with tumors, an increase in the number of side effects of cancer treatment have led to mortality ( 1, 2). Importantly, our results demonstrated that CYP induced an increase in the m6A level of JPH2 mRNA by upregulating methyltransferases METT元, leading to the reduction of JPH2 expression levels, as well as increased field potential duration and action potential duration in cardiomyocytes. Moreover, N6-methyladenosine (m6A) methylation sequencing and RNA sequencing suggested that CYP induced cardiotoxicity by dysregulating calcium signaling. Our data demonstrated that CYP-induced a prolonged cardiac QT interval and electromechanical coupling time courses accompanied by JPH2 downregulation. In this study, we used cell and animal models to investigate the effect of CYP on cardiomyocytes. Although it has received significant attention, the related mechanisms of CYP-induced cardiotoxicity remain largely unknown. Cyclophosphamide (CYP)-induced cardiotoxicity is a common side effect of cancer treatment.
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9/14/2023 0 Comments Bloon city blalapopolous
9/14/2023 0 Comments Svb venture debtOther providers will require a business to have enough runway – usually around six months’ worth. Requirements from providers vary, but generally, they require companies to have completed one or two funding rounds from private investors before backing them. You’re pushing the lender to act as a quasi-investor because they’re taking an earlier stage risk than most banks would ever touch.” W hat are the requirements? This is the first time these businesses take on debt. “It’s about the business plans, projections and prospects of the young business. “Lenders are trusting what the management tells them about the trajectory of a business,” Israel says. They will want an equity kicker, which is to say if your business is doing well, they’ll have a chunk of the shares at the end of the loan period. They may also take an equity warrant – a bit like a stock option. The interest rate is also higher – usually ranging between eight and 12 per cent – and pay-back terms tend to be shorter, usually between one and two years. So, while traditional banks require positive cashflow as proof you can pay back the loan, venture debt providers take into consideration venture capital raised and future revenue.Īs this is more risky than traditional loans for the lender, debt providers tend to follow venture capital investors they trust to give them the confidence in providing the loan. Debt serves high-growth, mostly pre-revenue start-ups backed by venture capital. Venture debt loans serve a different purpose to traditional bank loans. See also: Most active venture capital firms revealed Venture debt vs traditional loans Providers don’t require a member on the board, but in some cases can offer advice. Venture debt is an addition to venture capital and has the sole purpose of providing an early-stage business with liquidity in between funding rounds. VC investors are typically veterans in the industry who can link start-ups to contacts and provide advice. Venture capital provides capital in exchange for a slice of the business and usually a place on the board. The capital can then be used to finance R&D or purchasing equipment – the main benefactors tend to be companies in life sciences, SaaS and deep tech. “Typically, it is used for something more one-off, like a strategic move to a new market or an acquisition trail.”įounders can approach debt providers directly in between fundraising rounds, but sometimes venture capital firms will approach providers to help support a start-up. “You can use venture debt for a whole range of purposes,” Israel says. Venture debt serves two main purposes: to extend the runway of the equity round and act as a start-up’s insurance policy in the event costs are higher than expected. It means there is no dilution.” Why and when do you need venture debt? “Venture debt rides over that because there’s no need to amend the shareholder position. “It offers one core benefit for a company like that: by the time you’ve had two or three rounds of equity funding, you’ll potentially have quite a complicated cap structure, which means trying to do anything with shareholders becomes more complicated because you need lots of consent – it becomes a slow and perhaps cumbersome process. “Venture debt is essentially the first piece of debt a young, typically tech, company which has already had some – perhaps Series A or Series B – equity is going to take on,” Brett Israel of law firm Marriott Harrison tells Growth Business. The European Investment Bank likens the finance option to a student loan for a young business – where there are no assets to the company’s name but expect future earnings and returns. Venture debt can be offered to start-ups and scale-ups that don’t have significant assets and doesn’t require them to give up a stake – minimising the risk of equity dilution. It provides a start-up with liquidity between equity funding rounds and comes on top of venture capital, not instead of it. Venture debt is the loaning of capital to early stage, high-growth businesses which are backed by venture capital. But what exactly is venture debt? How do you get it and with the collapse and subsequent buyout of pioneer venture debt provider, Silicon Valley Bank (SVB), is it a good option for growing businesses right now? What is venture debt? 9/14/2023 0 Comments Best macbook pro privacy screenAll refunds will be refunded via the payment method the order was received. Orders may be subject to a 20% restocking fee and all shipping and handling charges are the responsibility of the customer. Products may be returned for a full refund of the product purchase price plus applicable taxes within 30 days of receipt. We're available to support you from Monday - Friday from 7:30am until 6:30pm PT. If you are not satisfied with your Kensington purchase, please call 1-80 within 30 days of receipt to obtain a Return Material Authorization (RMA) number and instructions. Magnets make it easy to detach and reattach The other side is glossy and provides a clearer view of the monitor. With reversible viewing options, one side has a matte finish to reduce glare and fingerprints.Low reflective coating reduces glare from outside light sources for improved viewing clarity.Blue light reduction filters out harmful rays by up to 22%, easing eye strain and reducing the chances of blue light interrupting natural sleep patterns.Limited viewing angle narrows the field of vision to +/- 30 degrees, helping keep the information on your screen private and reducing the chances of a visual data breach in the office or in public.Screen’s magnets help keep MacBook Pro closed so it can enter - and stay in - sleep mode with no need to remove after use.Privacy screen seamlessly and conveniently attaches to the MacBook Pro frame with magnets, avoids potentially damaging adhesives from being used, and eliminates any setup process.Includes anti-bacterial cleaning cloth and screen holder to protect from scratches while not in use. Reversible screen offers matte or glossy viewing options - magnets make it easy to detach and reattach. Reduces harmful blue light by up to 22%, diminishes glare, and improves clarity. Screen protects monitor from scratches and damage, while providing privacy by limiting viewing angle to +/- 30°. If you encounter any problems during installation and use, please feel free to contact us, we will reply quickly within 24 hours to solve any problems for you.The MagPro™ Elite Magnetic Privacy Screen for MacBook Pro 16" seamlessly attaches to the laptop’s magnetic frame, allowing the MacBook Pro to close completely and enter sleep mode - no need to remove. YEAHTU specializes in providing best-in-class privacy solutions to individuals, small businesses, corporations, government and educational institutions. Top Service: Your Magnetic Removable privacy screen supports unconditional return and exchange within 30 days, please buy MacBook Pro 14 inch screen protector with confidence. Our privacy screens also help protect your screen from dust and scratches. It limits viewing angle to +/- 30 degrees, data is visible only to persons directly in front of the monitor while prying eyes beside you see only NOTHING.Īnti-Glare Protector: macbook Pro 14 inch Privacy screen not only protects your privacy, but also has anti-blue light and anti-glare function to block glare and filter harmful blue light radiation to the eyes. Superior Privacy Protection: privacy screen macbook Pro 14 inch computer privacy screen filter is perfect for office, public, and high traffic areas. Note that when the privacy screen is turned off, your laptop won't shut down completely, but sleep mode is still supported. Magnetic Removable Installation: macbook Pro 14 inch screen protector, Simply place the privacy screen protector on the top of your MacBook Pro M1/M2, let the magnet stick to the top automatically adsorb, Easily remove and reconnect when needed. Please Confirm your MacBook Model Before Purchase. Macbook Pro 14.2 inch (Model: A2442/A2779) M1 Pro / M1 Max / M2 Pro / M2 Max chip. Compatible Model: Macbook Pro 14 inch Privacy Screen Protector is Specially Designed for 2021~2023 Release, Compatible with 9/14/2023 0 Comments Ceo dame dashIn addition to solidifying himself as a music mogul, Dash expanded his enterprise into the fashion and lifestyle space, growing Rocawear into a prominent urban apparel company that eventually sold to Iconix in 2007 for a reported $204 million. The label boasted a roster that included Kanye West, Jay-Z, Memphis Bleek, State Property, The Diplomats, Just Blaze and DJ Clue. While his position amongst the most influential people to shape Hip Hop culture can be debated in the court of popular opinion, what Dash embodies has undoubtedly paved a path for today's generation of independent creators and entrepreneurs.įounding Roc-A-Fella records in 1995, alongside Jay-Z and Kareem 'Biggs' Burke, the iconic rap imprint sold millions of units worldwide, releasing a decorated list of era-defining hits throughout a celebrated run that lasted nearly two decades. Though his message has taken many forms throughout the years, his core message remains consistent: be your own boss, own your influence and stay true to yourself at all times. His unfiltered and outspoken remarks have made headlines, unapologetically exposing industry powers for exploiting artists, copying trends and robbing creators. Labeled as a brash and polarizing figure in the music business, Dash developed a looming reputation for clashing with prominent executives over issues of ownership, value and properly respecting the culture. One entrepreneur who embodies this relentless spirit of independence is Dame Dash. Yet, the great reward of standing your ground amidst opposition is seeing what was once denied or dismissed manifest into a reality bigger than what you imagined. It takes courage to stand alone and fight for what you believe when the world can't conceive your vision. Surviving the scrutiny and persecution that accompany acts of rebellion demands an unapologetic attitude only a rare breed of leaders possess. Since trendsetters are tasked with bravely planting the flag first, being a trailblazer is a role reserved for the few that fearlessly embrace being ahead of their time.Īlthough these change-makers don't desire acceptance, withstanding the wrath of skepticism that inevitably follows the introduction of new ideas and ideologies is never easy. While history holds a place for visionaries who challenge the boundaries of possibility, pioneers aren't often praised for shifting paradigms and redefining business models in the moment. 9/14/2023 0 Comments Golden chicken breedNonetheless, they will not be the best meat bird around. Golden Comet chickens could be eaten for meat if you required to cull some non-productive layers in their progressing age. The anticipated lifetime is 10– 15 years, but 7 is typical for a lot of dual objective types. They are crossed mostly for the convenience of sexing chicks at hatching, all female chicks being golden, but additionally good egg production. The Golden Comet is a cross bred: New Hampshire and White Plymouth Rock, both hearty twin purpose breeds. These chickens originated in the USA as well as they were established with the intention of production adequate supply of eggs throughout the country. The type of chicken established as a result of breeding pure New Hampshire fowl and a White Rock hen. What age do golden comets start laying eggs? Watch on them, because when they hit 16 weeks, they simply might stun you with your very first egg! Origin Unlike other types, Golden Comet chickens are chilly durable (in fact, they do excellent with extremes of both cold and heat) and also you’ll likely have eggs all year. If you’re not planning on eating all these eggs instantly, having an ideal storage unit for them all is a must. Golden Comets lay brown eggs, and also they’re so prolific (they go down between 250 and also 320 eggs annually), that you can anticipate to have a fresh egg in your coop for each hen you have practically every day. In effect, to maintain your flock of you require a flock of White Rocks and also a number of New Hampshire roosters. If you intend to ‘develop’ a Golden Comet, this is the pairing you require. Remember the initial pairing was a New Hampshire fowl over a White Rock hen. You will certainly not get Golden Comet chicks from Golden Comet chickens, the spawn will be cross types. This is where the ‘crossbreed’ component comes to be vital. it has actually been bred out of them so if you intend to hatch out some chicks you will have to fire up the incubator. Real to their reputation for manufacturing, these girls can begin laying at 16 weeks and will continue to be extremely efficient as much as around both year mark, afterwards egg production will leave significantly. They have the ability to put out a whopping 330 eggs annually– that’s practically an egg everyday! They can lay from 5-6 eggs weekly which places them comparable with the Rhode Island Red hen. Golden Comets are superb layers of tool to large brownish eggs. As adults, hens are reddish brownish and also white, as well as fowls are all white to white with a scattering of red feathers. Female chicks are bronzy buff color with stripes, and men are light yellow. They are superb around kids and are a great novice type for anybody wanting to start their very own backyard flock of chickens. Golden Comet chickens are sociable with strangers as well as don’t mind being held by a person they have never ever satisfied before. In the video clip, Marsala attempts to bully one of the meaties and also as soon as Rosemary, the Golden Comet, saw what was happening, she moved away. They are rarely entailed in “arguments” with other chickens.Įven when they were more youthful, both Golden Comets in my flock never obtained involved in any scuffles. They will certainly stroll right up to you just because of the easy reality you are there.įrom what I have actually observed in my own flock, when there is a scuffle going on, the Golden Comet hens are nowhere around it. The chickens are incredibly pleasant as well as curious concerning everything they see. My chickens don’t fuss in any way when I pick them up. Speaking from my own individual experience, this breed of chicken is very laid back. They get along and also proactively pursue forage. These energetic birds exhibit confidence and also persistence. Regardless of which name you know them by, this info will relate to all due to the fact that they coincide chicken breed. Some of the alternate names that you might hear for this type of chicken are: These chickens go by other breed names as well. These chickens seldom go broody so hatching eggs from this breed will certainly need to be completed through an incubator. The resulting chick will certainly be a second generation of mixed breed chicken. A Golden Comet will certainly not create an additional Golden Comet if her eggs are hatched that have actually been fed by a Golden Comet rooster. The one actual downside to this type is breeding itself. As a result of their smaller size, they are ruled out an excellent choice as meat birds. The hens are seldom larger than four extra pounds and the fowls seldom get to a dimension above 6 extra pounds. Golden Comet chickens are a smaller type that makes them good for egg manufacturing just. Here I mainly write about music and videogames, but everything that has to do with the creation of parallel worlds fascinates me. Developed by Tender Claws, Stranger Things VR will have you playing as Vecna seeking revenge on Eleven and Hawkins. Pre-orders are now available on the Oculus Store at a discount price of 26.99. Otherwise I’m 30 and a musician, singer and songwriter. Netflix had fixed that with a new gameplay trailer, as well as narrowing down a Fall 2023 release date for the Meta Quest 2 and Meta Quest Pro. Writing is my passion, music is my life and Liam Gallagher my God. Universal Studios’ Halloween Horror Nights brings season 4 of Stranger Things to life in a terrifying all-new haunted house, beginning Friday, September 1 at Universal Orlando and Thursday, September 7 at Universal Hollywood. At the moment, very little is known about the project. “The Stranger Things games that we have, for example, are fantastic, but I don’t think we have made the Stranger Things game yet, the one that is truly connected to the universe and the characters that fans love,” said Loombe.Ī few months ago Netflix also announced that Stranger Things VR would arrive by the end of 2023, a virtual reality game that will put players in Vecna’s shoes. Let’s remember that triple-A games mean high-level titles, with big budgets and with well-known development studios. “As we launch more and more games we are learning a lot from the industry and preparing ever more complex gaming experiences through AAA studios,” said Leanne Loombe. Pop pills to keep the pain away, deftly dodge while unloading your weapons with bullet time mechanics, and don’t stop running.Įl Paso, Elsewhere is currently set for release on September 26 for the Xbox One, Xbox Series, and PC via Steam.What can we expect from the new Stranger Things game You’ll have to make your way through 40 floors of action, battling against classic horror icons, from mummies and werewolves to biblically accurate angels. Armed with shotguns, pistols, uzis, stakes, and more, the only option players have is to keep killing to save the world and push back Savage’s most painful memories. This was always going to be a one-way trip, no matter the monsters slain or the pills taken.Įl Paso, Elsewhere puts you in the twisting void beneath an unassuming motel, where James Savage must dive down a reality-bending path to stop Draculae. Revisiting the dire situation that brought him back to his hometown and on a collision course with his former love, this trailer has Savage coming to terms with what’s ahead of him. Unlike last month’s stylish trailer, this one hits home that things aren’t so cut and dry with El Paso, Elsewhere protagonist James Savage, as he’s up against his ex known as “Draculae”. and Strange Scaffold know how to keep the neo-noir vibes coming with the latest trailer for their upcoming shooter El Paso, Elsewhere. Meanwhile, the fifth and final season of Stranger Things is set for a 2024 release. The original announcement stated that you’ll become an “explorer of unknown realities as you form the hive mind and tame the void.” You’ll also be able to invade minds and conjure nightmares in your quest for revenge. The new trailer unveiled during the Meta Quest Gaming Showcase gives you a taste of some of the things you’ll be doing in the Upside Down, including combat and the eventual crossing over through gates. Players will invade the dreams and memories of fan-favorite characters and harness telekinetic powers to possess minds and battle creatures, as Henry Creel’s transformation into Vecna and his influence on the events of prior seasons is revealed. Invade minds and conjure nightmares in your quest to. Stranger Things VR - Official Announcement from Netflix videoStranger Things VR- Trailer Check out this new trailer for Stranger Things VR, which shows us 40 from the upcoming action/horror. Pre-orders are now available on the Oculus Store at a discount price of $26.99.ĭeveloped by Tender Claws, Stranger Things VR will have you playing as Vecna seeking revenge on Eleven and Hawkins. Become an explorer of unknown realities as you form the hive mind and tame the void. Netflix had fixed that with a new gameplay trailer, as well as narrowing down a Fall 2023 release date for the Meta Quest 2 and Meta Quest Pro. Apart from the announcement trailer, we didn’t get much else. Back in November, Netflix teased that they were in the process of developing Stranger Things VR. 9/14/2023 0 Comments Interview vimeo ceo anjali sud b2bI was drawn to Vimeo for three specific reasons. I could have a more outsized impact on a smaller company’s future. When I went to Vimeo, it was because I was interested in impact. This is a hard area for smaller companies to master, but as we scale, I see the value of it more and more.Įrik Roth: What was it about a start-up like Vimeo that attracted you when it was so vastly different from investment banking and a big engine like Amazon?Īnjali Sud: I always define my experience at Amazon in terms of learning. Yet another aspect is the ethos of continuous improvement: the internal tooling of everything to be operationalized and scalable, a constant desire to increase efficiency of every single thing you did. The second is the willingness to forgo near-term profit in order to improve the value proposition. We would always start with the customer: you would write a press release of what the experience would be like for the customer before you even built a product. One that stands out is customer obsession, something Amazon is known for. While I am not a traditional innovator, I’m quite proud of the amount of innovation that Vimeo has led in the past four years.Įrik Roth: What lessons did you take away from your time at Amazon that helped you at Vimeo?Īnjali Sud: I took a lot of the company’s values with me when I came to Vimeo. There was a clear hierarchy of folks above me, and I never thought that three years later I would be stepping in as CEO to substantially pivot the platform. I came to Vimeo to run marketing-a traditional executive job. I then moved to Amazon, where I got to experience many different functions and jobs. I started in investment banking and spent several years at Time Warner just as technology and media companies began unbundling. To be candid, I never thought of myself as an innovator and certainly not as an entrepreneur. Where did you start and how did you get to Vimeo?Īnjali Sud: I’ve had a pretty winding career path. As you can imagine, that has become more relevant during the pandemic.Įrik Roth: Let’s talk about your journey. We think of ourselves as the mission control powering every professional team in the world that wants to communicate using video. We are a platform that helps anyone create and distribute video anywhere on the internet. Erik Roth: Can you first explain what exactly Vimeo is and does?Īnjali Sud: Vimeo is the world’s largest professional video platform and community. 9/13/2023 0 Comments Find tagged pictures instagram(Just keep in mind that tagging is an easy way for people to create links from their updates to your Page, and that by preventing tagging altogether, you’re limiting their ability to send people in your direction!) If you want to upload photos without allowing people to tag them, you have that option – and you can prevent people from tagging your Page altogether, if you want. On your Facebook Page, go to settings, and you’ll see these options: Nobody can tag your Facebook Page unless you want them to – nor can they tag the media your Page uploads. Pages, on the other hand, DO have that option. While Facebook profiles have tools like tag review and timeline review, they don’t have the option to completely prevent being tagged in the first place. Pages have a LOT more control over who can tag them. That’s just what Facebook profiles can control – and just like before, the way this stuff works with Pages is just a little bit different. (And don’t forget, people can always untag themselves from photos and videos after you tag them – even if they previously approved of the tag.) The photo is still tagged but it is not on your timeline. You are then allowed to decide whether or not the post with that tag appears in your own Timeline. The important differentiator is that Facebook timeline review is not how to remove a tag on Facebook. Timeline review is when you (a Facebook user) get notified anytime someone tags you in a post. You receive that notification before the tag is approved for public view, so you get to decide whether or not the tag is allowed. Tag review is when you (a Facebook user) get notified anytime someone tries to add a tag to one of your Facebook posts. (And they have VERY similar names, so pay close attention to this part!) That’s why Facebook has two different options for reviewing tags and controlling their visibility. Not everybody wants to be tagged in things without a little warning – or without having some say in the visibility of those tags. It gets a little more complicated when you factor in Facebook’s options for reviewing tags. If your profile is Facebook friends with someone, though, you can tag them on your own Facebook Page’s photos or videos, even if they haven’t liked that Page! If you’re a Page, though, the rules about how to tag on Facebook are a little different – and a LOT trickier.įor example, your Facebook Page can tag people in its videos or photos – but only if that person has liked your Page. (So you can tag Vin Diesel’s Facebook Page in your Chronicles of Riddick fan art, even if you haven’t yet followed it.) Using default privacy settings, Facebook profiles can someone on Facebook, and they can tag Pages – whether or not they’ve liked that those Pages. (Even for pros, it can get kind of confusing.) So right now, it’s time for a quick refresher on how to tag someone in a post on Facebook, how to enable tagging on Facebook, and what you can and can’t do when tagging people and Pages.įor starters… Why can’t I tag someone on Facebook? Because anyone can tag a Page – but tagging a person doesn’t always work. Tagging users and Pages in photos and status updates is a perfectly convenient way to make sure they get noticed – or get credit!īut there are a lot of weird little rules and settings regarding how to tag on Facebook, including differences between what you can do as a person and what you can do as a Page. You probably came to this page because you’re wondering – why can’t I tag someone on Facebook? That’s why it’s so important to know exactly how Facebook’s different features work.Īnd one of the most important ones to understand is tagging. On the other hand, though, you don’t necessarily want to give up all your privacy – and as useful as features like facial recognition can be, they can also feel just a teensy bit creepy. On the one hand, you want to make yourself as accessible as possible, so that new friends and followers can find you, and you can expand your network. Facebook photo privacy is a tricky thing. 9/13/2023 0 Comments Black forest valheim locationThe most important resource in the swamps is Scrap Iron, which you can use to make the next tier of gear after Bronze. How To Find Iron In Swamps Look for Sunken Crypts in Swamps and make note of their locations, because they're full of useful resources-Scrap Iron most of all. If not, try to quickly melee them before they can do too much damage, as they hit hard when they're up close. If you can put some distance on them or spot them before they spot you, they're fairly easy to drop with a bow and have no ranged attacks, however. They move very quickly as they cross land, making it tough to get away from them. Wraiths are ghostly flying enemies, and they can be a real pain. Since they can't get out of the water, though, you can nail them with arrows pretty easily and collect the very useful Bloodbags they drop. Leeches can also wreak havoc on your boats and sink rafts pretty easily, so stay clear of them. They're not especially dangerous because they can't leave the water, but if they get you while you're too close, you'll be poisoned. Watch out for these big black monsters in the waterways of the swamp. Higher-level red blobs will split into two smaller green ones when killed. Blobs don't hit very hard but if you get close to them, they'll release a poisonous cloud, so try to keep your distance from them and take them out with your bow. They're also more willing to go underwater than most enemies. These green masses of goo can be unpredictable as they jump toward you. Parrying them can make them easier to take down, but beware of the ones with bows especially, because they can do a lot of damage and be tough to avoid. These zombie-like fighters are tougher than skeletons and can do a lot more damage. They're not especially strong in the Swamp, but their arrows can be a pain when you're battling other enemies. Like in the other biomes, skeletons have either swords and shields or bows. Here's what you'll face in the Swamp biome. The swamps are home to some dangerous creatures, most notably because a bunch of them can inflict you with poison, which can do devastating damage over time.
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